Interpersonal neurobiology (IPNB) is an interdisciplinary framework, developed by psychiatrist Daniel J. Siegel, that integrates neuroscience, psychology, and the study of relationships to explain the mind and well-being.
Interpersonal neurobiology draws together findings from across the sciences — including neuroscience, developmental psychology, attachment theory, and systems thinking — to describe how the mind emerges from the interaction of brain, body, and relationships. The term was coined by Daniel J. Siegel in his 1999 book The Developing Mind, and the framework treats the mind partly as an embodied and relational process that regulates the flow of energy and information.
A central concept is integration: the linkage of differentiated parts of a system, whether within one person or among several. Siegel frames integration as the basis of mental health, producing states that are flexible, adaptive, coherent, energized, and stable. The framework underpins his "mindsight" approach and has influenced psychotherapy, parenting, education, and mindfulness practice by emphasizing that relationships physically shape the developing brain.